Rapid new test transforms brain tumour diagnosis

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1:00It's everything your business needs in one place, saving you time, headaches and serious money. Stop paying for missing pieces, go to odu.com. That's odu.com to learn more. This is the global news podcast from the BBC World Service. Hello, I'm Oliver Conway. We're recording this at 14 hours GMT on Friday the 25th of September. A new test for brain tumors can slash diagnosis time to just two hours. President Zelensky says the US will allow Ukraine to produce patriot missiles, despite a previous U-turn. And a Filipino maid who narrowly escaped execution in Indonesia has been pardoned. Also in this podcast. Toner face washed, ronda, blush and contour. Miscarre, lip glosses and lip balms. Campaigners call for better regulation of skincare and makeup for children.

2:00A new rapid test for brain tumors can slash diagnosis time to just two hours, meaning patients no longer have to wait weeks for news. It means surgeons can get results even while they're operating. Hospitals in the UK are trialling the test as our medical editor, Fergus Walsh, reports. Steve Palmer is being wheeled to the operating theatres at Queen's Medical Centre, notting them in the heart of the UK. The 55-year-old collapsed a few weeks ago and was diagnosed with a brain tumor. It has been prepped for surgery. Hopefully all of it removed and would be great. Then it can get on with recovery and whatever comes next and then it's getting back to hopefully some normality. So this is the scan of Stephen's head, a bother computer system. In theatre, neurosurgeons Stuart Smith is reviewing MRI scans. This is the right front and lower where the white area represents the tumor within his brain

3:02that we're going to be operating on today. How big is that? So this tumor is about 5 or 6 centimeters across in total. More than 12,000 people a year are diagnosed with a brain tumor in the UK alone. There are more than 150 different types and a thorough genetic analysis means a definitive diagnosis can take 6 to 8 weeks after surgery, not this time. Once Steve's tumor is exposed, the surgeon's carefully select tissue samples. Damaged by any of the surgical techniques, this all looks viable, it doesn't look lacrosic and then top right. These contain all the genetic information needed to grade and diagnose his tumor. They're bagged up and taken to the pathology labs. The rapid genomic test was developed by scientists at the University of Nottingham in partnership with hospital clinicians. And what we're hoping to have in 90 minutes or so will be a confident, comprehensive, molecular

4:06classification. The samples are fed into an ultra-rapid sequencing machine, the size of a shoe box. Molecules of DNA pass through a nanopore or tiny hole, which reveals the tumor's unique genomic fingerprint. The nanopore is running now. It's been running for about 20 minutes. Dr. Simon Payne, consultant neuro pathologist at Nottingham University Hospitals, phones the operating theatre with the results. The bigger picture and those copy number changes, I think this would be most and keep me the glide best, Emma. Neurosurgeon Stuart Smith has taken the call. Yeah, I think we've probably done as much as we've been having taken out the visible tumor. Great. Well, thank you Emma. That's really helpful and that will help us finish up the operation. A definitive diagnosis has taken just two hours, with Steve Palmer still on the operating table.

5:06Neurosurgeon Stuart Smith says it's an extraordinary medical advance. It seems almost magical that you can do things that quickly, but this adds a whole new level of information that will guide the surgeon, allow us to make more accurate decisions about how much surgery we do, how extensive that operation is. Hi, Stephen, how are you? Oh, okay. Neurosurgeon Stuart Smith is able to feedback the results and a treatment plan to Steve within days rather than many weeks. I'm afraid it's not great in using what type of tumor it is. It is one of these grade four tumors and the name for that type of tumor is Glyablastoma. But it does mean chemo and radiotherapy can start sooner. The other benefit of getting all the genetic diagnosis means that we have a full genetic profile of the tumor and that hopefully will open the door to clinical trials for you. There's a national programme being there. Obviously, it wasn't all wanted to hear, but for me getting that quick diagnosis, let's

6:14go on to the next phase of treatment and recovery and get on to fighting whatever I've got to fight. So it did help remove potentially weeks of anxiety? Oh, God, yeah, absolutely. Ukraine has been hit hard by Russia's current air campaign. There are three people were killed in Kiev this afternoon. Part of the problem is a lack of missile interceptors such as the US supplied Patriots. In July, Donald Trump told Vladimir Zelensky to make them yourself only to then change his mind. Now though, the Ukrainian president says the US leader has made a final decision to give Ukraine licenses to produce them. Sasha Schlichter told me more. I think the president's Zelensky is keeping his fingers crossed because we know that Donald Trump can change his mind in one day several times. So his latest opinion, according to Mr. Zelensky, is that the final decision has been made and there will be permission for Ukraine to produce its own missiles, its own Patriot

7:20interceptors. But it's funny that in July, Mr. Trump was so keen. He said it would be pretty cool to grant Ukraine the licenses. Three weeks later, he said America should be very careful before granting Ukraine authorization without any reference to the fact that he was very enthusiastic. So what happened between these two events? Who knows? Maybe Mr. Steve Whitkov had a conversation with his friend Vladimir Putin and Mr. Putin gave him another history lesson and said that interceptor missiles in the hands of that Nazi, he calls him Nazi, Zelensky is a very dangerous thing. And Mr. Whitkov of course reported this straight to Mr. Trump. So it's all, you should be very, very sure-footed and of course Mr. Zelensky should be very careful not to antagonize Mr. Trump so he never recalled him flipping over this issue. He's just said it as it is.

8:22But if and when Ukraine get these licenses, it won't be a magic bullet? No, it takes months and months up to two years to set up production, you know, the building of the engine, the rocket itself. The systems are there, it's just the rockets that are depleted. And of course, even if it wanted to, Washington couldn't supply Ukraine now with already made rockets because its stocks have been depleted in the Middle East and it's a very, very costly weapon, really costly weapon, because billions and millions and they used it on nothing in the Middle East because they were so keen to show that it is such a victorious war on Iran. So now the Pentagon has its own stocks depleted so all it can do is give a license to Ukraine to produce. But I must say that the war has changed completely. Zelensky has said today that Ukraine is working on its own anti-balistic system which is called

9:26frayer with the participation of several European countries. Our Global Affairs reporter Sasha Schlichler. Mary Jane Veloso spent nearly 15 years on death row in Indonesia in a case that highlighted issues over the treatment of Filipino domestic workers abroad. The former made narrowly escaped execution by firing squad after being found carrying heroin through an airport. She says she was tricked into it and she's now been pardoned by the Philippine president. Between Congresswoman Sarah Elago said justice had finally been done. The granting of absolute pardon to Mary Jane Veloso is a victory of the people's movement. For the past 15 years have tirelessly fought and stood with her for justice. I got the details from our Southeast Asia correspondent Jonathan Head. He was always likely she was going to be pardoned. She was long negotiations between the Philippine government in Indonesia over her case. Going right back to when she was first sentenced to death, President Markos finally agreed on

10:31what you might call a prisoner transfer arrangement which hadn't existed between the two countries back in 2024. And that allowed her to be moved back to the Philippines to serve the rest of her sentence. It was commuted from a death sentence to a life sentence because the Philippines didn't have the death penalty. But given the enormous amount of sympathy for her in the Philippines, it was kind of inevitable that after a decent interval that the president would pardon her widely expected, it is also a popular thing to do for a president who lacks popularity at the moment. I mean inside the Philippines, I mean she was seen very much as a victim of human trafficking. There are the people who actually arranged her journey to Indonesia have been themselves sentenced to life imprisonment in the Philippines for people trafficking. And of course she's always said that the drugs were planted in the suitcase. I mean she came from a very poor background and her situation as a migrant worker desperately seeking employment in other countries resonates in a country.

11:31The Philippines which sends millions of people overseas every year to work. It's part of the economy everyone's used to it. But they also know that these people are very vulnerable to being exploited or being trafficked and so I think everyone knew this situation was coming and president Markus has done it basically after a decent number of months after her return from Indonesia. Yeah and how did she end up on death row in Indonesia? She arrived in Jacques de Carso, the Indonesian city in April of 2010 and the customs officers there found 2.6 kilos of heroin sewn into the lining of her suitcase. Now she'd been overseas to work before. She was desperately looking for work and she said the job had been arranged for. In fact she thought she was going for a job in Malaysia and then the people organizing it suddenly said to her go to Indonesia. She always said that the suitcase was simply given to her because she didn't have one to put some more clothes into. The Indonesian court was unsympathetic. At the time Indonesia was running a very harsh anti-drugs campaign under president Jokkawidodo.

12:36The court frankly was a very unfair trial. She didn't speak in Indonesia, she didn't understand of what was happening. But the appeals against her death sentence failed and she was in fact scheduled to be executed in 2015 along with eight other defendants, convicts including two Australians. They were executed, she wasn't. But partly because there was also an anti-drugs campaign at the Philippines at the time. President Duterte said for many years that he wouldn't intervene in her case. It's only recently that the new government and the Philippines has really pushed to get her released. Our Southeast Asia correspondent Jonathan Head. Still succumb in this podcast. As we look into a world where human thought is being replaced by machines, it is so important that the conditions of human dignity must be respected and be at the forefront.

13:36On a visit to France, Pope Leo gives his thoughts on artificial intelligence. Hey, it's Tories Spelling. Actress, podcast host and mom. Back to school may add another layer of busy, but I don't cut corners when it comes to my family and nutrition. Good nutrition is necessary for learning activity and development and nutrient dense foods like protein pack, lean beef. Provide key nutrients to fuel the whole family. Visit backtoschoolcalifornia.com for money saving offers on beef, delicious recipes and more. Back to school nutrition starts with backtoschoolcalifornia.com. Self-directed investing. Trading. Full service wealth management. Automated investing. Financial planning. Thematic investing. Retirement planning. Few. And to think. That's just a small taste of what Schwab offers. Like a Schwab knows that when it comes to your finances, choice matters.

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15:42ones to help avoid costly mistakes. Listen to choiceology at Schwab.com slash podcast or wherever you listen. This is the Global News Podcast. The World Health Organization has warned that the Democratic Republic of Congo is running short of health workers to treat the continuing Ebola outbreak there. Cases have surged by 73% over the past three weeks in northern Keevue province, and there have now been more than 3,700 deaths. Dr. Rupert Nara has worked for Medesan San Frontea for many years and says nothing compares to what she witnessed while working for six weeks in Brutembo, a city in northern Congo. Six weeks doesn't sound like a long time for me. Normally, my missions are about six months, but I will say this. Those six weeks felt like six years at times. It was probably the most difficult thing I've ever done in my life, and luckily I had incredible

16:44Congolese staff and colleagues to work with, but it was a very challenging experience. So in Brutembo, we have a 30-bed of bullet treatment unit isolation area, and out of those beds, at least 20 to 30% of those cases were pediatric cases, and most of these were children that were quite young. Most of them were children under five years of age. On average, one and a half years, when you looked at all the kids, we were receiving including newborns, and it was incredibly challenging. One patient in particular that comes into my mind was a young woman with her child, and she had one sandalon, and none of her papers of her or her name, or where she's born, or her child, because she had just fled conflict in another area. And she lost a lot of her family members to this conflict, and she came in, and both

17:50her and her child, headabola. And to think about what this poor population is suffering, it's impossible to understand and realize the pain, the suffering, but also the resilience in this incredible population. And unfortunately, we did lose that child of hers, that baby died, and the woman did survive, but every day felt impossible. We lose a lot of those children. I think we lost between 80 to 90% of these kids while I was there. It's incredibly challenging. I was mainly there to work both as a pediatrician, but also train our Congolese colleagues in pediatric management and critical care. And that was my silver lining, because I had really incredible stuff that was risking

18:51their life every day. And although it was a very challenging six weeks, I just got home, and I received several messages from my staff over the last two days, because we had four kids admitted when I left. And two of those children have left cured. One was a two and a half year old. One is a seven year old. And the two other children that were confirmed, one's a 15-month old, and the other one's another two year old, are actually stable and doing well. And it's really nice to hear and see my staff see some hope. Dr. Rupert Nara The catastrophic flood in Nepal last month killed at least 1,400 people, with more than 6,000 still missing. Scientists say it was caused by a glacier collapse. Nepal contributes less than 0.1% to greenhouse gas emissions, but the disaster is a reminder

19:52that the effects of global warming aren't limited to the biggest polluters. It is the Napoleon Prime Minister, Belendra Shah, at the UN General Assembly. Four weeks ago, the world saw shocking images of catastrophic floods that swept away Nepal's mountain communities. It was a warning to the world, and I ask you today, every really heard that warning. Nearly three years ago, standing in the shadow of our Mount Everest, the Secretary General of United Nations, warned humanity about the madness and impending climate disaster. That cry from the rooftop of the world was not heard enough loudly. We in Nepal heard it. Our community is heard it. But will his comments make any difference? I asked our global environment correspondent, Navin Sinkhatka. The way it has been drafted that speech, many are saying it was quite powerful. Of course, there are debates that the delivery might happen better, but the message is what matters they say. Many people. What they say is he's kind of really, really broad this thing up that the world knows about

20:53it, but the global leaders who are there now for the UN General Assembly, they haven't acted. That's the point. He's hammering. He's also talking about this financing mechanism, how difficult it is to get money. One quote I'll read for you, what he says is, when the house is burning, we do ask the family to complete forms of the forms. Meaning, it takes time, takes lots of energy. You just act. That is what he is trying to say. In fact, the foreign minister has been saying the same thing, the same venue, regarding the Himalayan climate resilience mechanism. I'm still trying to gather what are those things. He's talked about satellite information, early warnings, and then post disaster, transplant recovery, and so on and so forth. But I think we haven't yet seen the real blueprint. What is that? The level was the timeframe. And most importantly, has India and China been consulted?

21:54Have they been discussed? Because we haven't seen any response from them. Unless these two giants of the region, unless they cooperate, nothing is going to happen. And also quickly, we know that the Himalayan region between China and India has actually been a flashpoint. We have reported this in the past. So how will that change into cooperation? That's a Himalayan task. I believe it happens. But it's a big, big achievement. And what is happening on the ground in that area that was hit by that wall of water and mud? It's a very slow thing. We are seeing pictures and views said by people on the ground. They're trying their best to cut through the road. Imagine still we see three, four-storyed houses buried. So digging through that is a massive thing. And that's where the money thing comes. Money is still not there. And that's what they're complaining about. Navin Sinkhakya. Duty products like skincare and makeup have become a big part of young people's lives in recent years, often driven by social media.

22:55In some cases, children may even be harming themselves. BBC reporter Nina Blissett asks some children what they use. Toner face washed, runger, blush and contour, mascara, lip glosses and lip balms, stuff for my eyebrows, cleanser, moisturizer, blush and eyeshadow, blush, maybe a bit of concealer and obviously mascara. Where do you see all these makeup and skincare products? A lot of people post about it like their morning routines. Idols like the public, like social media would say. I just saw it around TikTok, YouTube and stuff and I just thought why not try it? Well, save face, a British organisation that runs a register of approved beauty professionals is calling for better regulation. It's found that it's Ashton Collins. It's become a huge, huge problem and it's only going to get worse and that's why we're calling for this urgent intervention to have clear labelling on products to inform parents and the children and retail staff that actually these are harmful ingredients for children

23:57and they're not suitable for people under 18. Powerful active skin care ingredients like retinols and certain acids, they work by speeding up this skin cell turnover and so they're exfoliants. And for young skin whose barriers are really sensitive, it damages their skin and damages it long-term and so it can cause things like burning and contact dermatitis and exema long-term and not just the physical impact it has on our young children. It's also the mental health impact telling children as young as eight that you need these extensive skin care routines or you need to improve the way that you look. I think he's really harmful. We probably naively thought that once these companies realise the impact they have in on young children's health and their mental health they would step up to the plate and actually do that voluntarily but that isn't the case which is why we're now calling for government back in to better regulate social media companies and influencers in terms of how they target young children with these types of products.

24:58Ashton Collins from Save Face Although it's a secular state, France remains a nominally Catholic country albeit with a low church attendance. And there was a warm welcome for Pope Leo today. The bells of Notre Dame rang out as the pontiff landed at the airport to be greeted by President Macron and a military band. The highlight is expected to be a giant mass attended by more than half a million people in the centre of Paris. But in his first engagement of the four-day trip at the Elise Palace, he issued a warning about AI. As we look into a world where human thought is being replaced by machines, it is so important that the conditions of human dignity must be respected and be at the forefront. It is our questions of ethics to know what morally is good or not.

25:59So what are we to make of that? I asked our correspondent Hugh Scofield in Paris. We know that he holds AI as a theme very close to his heart. He issued his first ever encyclical that his papal pronouncement on the subject in May. He named himself Leigh the 14th, after Leigh the 13th, who was the Pope 100 years ago, who made some very important pronouncements about changing society then, industrialisation, the proletariat, the need for a human input into the changes then. He wants the same now. He wants human beings to consider very deeply the impact of AI. And that's the burden of his speech here in Rome all over the place. Not unusual they should say it here because he's got an audience now, or France and the world. And he's again insisting that AI in itself may not be immoral, but it is a dangerous thing which needs to be brought under control and the people who are in control of it need to be themselves ethically very, very conscientious. Now in that speech in front of President Macron and Assembly guests in the Alise,

27:04he reiterated the Church's opposition to assisted dying two months after France approved Euthanasia for those with incurable diseases. How might that message go down? It's the Church's message. It doesn't vary a jot from everything that the Church has said since this debate births forth, many decades ago about assisted dying and so on. So it is probably natural that the Pope would say this in France in front of his audience, that the Pope's position, the Church's position is opposition to assisted dying or position to anything that detracts from this essential tenet of the sanctity of human life. He made the same point about surrogacy, the buying of organs as well. These are things which the Church has a very strong and known position about. So it's not surprising that he said it here. It was listened to politely. The state, France has a different view. It's passed the law, as you say, which allows some assisted dying in certain circumstances. It's simply a stating of side. And that's important, but of course the Pope only has so much influence in France.

28:06He says for the rest to say, some people listen, some people don't. Yeah, I mean, how popular is he in France? As things stand, he's very, very popular. I mean, obviously the faithful are extremely excited about him, but on the left as well, people are generally anti-curricular. I think they approve of a lot of what he's had to say about poverty migration. And of course, AI. At Verbo, we understand that even the best of plans sometimes need a little support. So we plan for the plot twists. Every booking is automatically backed by our Verbo care guarantee, giving you confidence

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