PubReading [152] - Teaching photosensitizers a new trick: red light-triggered G-quadruplex alkylation by ligand co-localization - E. Cadoni, A. Madder et al
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We propose a bimolecular approach for G-quadruplex alkylation, using a pro-reactive furan-containing ligand, activated by red-light irradiation of a proximate G4-binding photosensitizer. G4- over dsDNA alkylation can be achieved selectively and proves high-yielding at low ligand excess. HPLC and modelling studies allowed identifying potential residues involved in the alkylation.
DOI: 10.1039/d0cc06030e - 2021
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