Evolving Role of B7-H3–Directed ADCs in the Extensive-Stage Small-Cell Lung Cancer Treatment Landscape

In this podcast episode, Charles Rudin, MD, PhD, and Mark A. Socinski, MD, discuss current gaps and clinical needs for patients with relapsed ES-SCLC, and the evolving role of B7-H3–directed antibody–drug conjugates in the management of patients with ES-SCLC, including:

• Clinical needs for relapsed ES-SCLC
• Scientific rationale for targeting B7-H3 and other tumor-associated antigens in SCLC
• ADCs, T-cell engagers, chemotherapy-based approaches, maintenance strategies, and ongoing clinical trials for ES-SCLC
• Recent efficacy and safety data for B7-H3–directed ADCs in ES-SCLC, including I-DXd
• Personalization of care of patients with SCLC, including patient-specific factors influencing treatment
• Case discussion of a patient with ES-SCLC requiring optimal next best treatment
• Importance of enrolling patients in ongoing trials of investigational agents for patients with ES-SCLC

Presenters:
Charles Rudin, MD, PhD
Cancer Center Director
Memorial Sloan Kettering Cancer Center
New York, New York

Mark A. Socinski, MD
Executive Medical Director
AdventHealth Cancer Institute
Orlando, Florida

Link to full program:
https://bit.ly/3UBEeYz

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