Do GLP-1s Actually Reverse Diabetes? The Truth About Diabetes Remission

Are GLP-1 medications like Ozempic, Mounjaro, and tirzepatide actually reversing Type 2 diabetes—or just putting it on pause? In this episode of The Living Life Well Show, Dr. Jon Skelton breaks down the latest research on GLP-1s and diabetes remission, including a landmark 2025 Lancet study of over 14,000 patients and the SURPASS trials on tirzepatide.

What you'll learn:

• How "diabetes remission" is defined—and why the definition matters
• The real remission rates: from 5.8% (strict, medication-free) to 18.3% (broadest definition)
• How long remission actually lasts once you stop a GLP-1 (hint: it's measured in months, not years)
• Who is most likely to achieve remission—and who is not
• Tirzepatide (Mounjaro) vs. semaglutide (Ozempic): what the SURPASS trials revealed
• What happens to your A1C and weight when you stop a GLP-1
• Why GLP-1s can be a powerful kickstart—but not a standalone solution
• The role of visceral fat, gut health, and thyroid function in metabolic health

Key terms & topics: GLP-1 medications, Type 2 diabetes remission, hemoglobin A1C, tirzepatide, semaglutide, Ozempic, Mounjaro, insulin resistance, visceral fat, weight loss, metabolic health, SURPASS trials, Lancet 2025 study, diabetes reversal

Episode Chapters:

• 0:00 — Introduction
• 0:28 — What the 2025 Lancet Study Found
• 1:19 — How Remission Is Defined
• 2:51 — Who Actually Achieves Remission?
• 6:36 — Tirzepatide & the SURPASS Trials
• 10:39 — What Happens When You Stop a GLP-1
• 15:00 — More Than Just A1C: The Bigger Picture
• 18:05 — GLP-1s as a Kickstart, Not a Crutch
• 19:49 — How to Get Help

Ready to take the next step? Schedule a free discovery call with the Live Life Well Clinic at https://livelifewellclinic.com/

Learn more about the Metabolic Reset Course:  Take me to the Metabolic Reset

If you enjoyed this episode, please subscribe, rate, and share it with someone who might benefit.

Disclaimer: This podcast is for entertainment and educational purposes only and is not meant to diagnose, treat, or cure any condition. Please consult a qualified medical professional for your specific needs.