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脑内神经细胞外β淀粉样蛋白沉积(又称老年斑)是阿尔茨海默病的主要病变，β淀粉样蛋白学说也被认为是阿尔茨海默病主流的发病机制。近期，一项最新研究颠覆了这一传统印象，提出“先有神经细胞死亡，后有细胞外淀粉样斑块出现”。
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