
Don’t Die with Bryan Johnson : 1211
About this episode
Today, we’re unlocking the full potential of your brain—starting with Bryan Johnson’s Blueprint for longevity and brain optimization.
We’re revisiting our conversation with Bryan, the creator of the Don’t Die movement (among many other things), to explore how his groundbreaking approach to brain health and biohacking is reshaping the future of longevity.
First, we dive into Bryan’s mission to make brain monitoring as easy as tracking blood glucose, using his Blueprint protocol to measure and optimize cognitive performance for better health and wellness.
Then, we tackle the deeper side of biohacking—longevity, societal reactions to living longer, and how to handle critics when you’re pushing the limits of human potential.
Finally, Bryan shares his personal journey—investing $80M into brain science, building the Blueprint for optimal living, and discovering the power of community and lifelong friendships for a long, vibrant life. This episode will change the way you think about brain health and the future of humanity.
Sponsors:
- Zbiotics | Go to https://zbiotics.com/DAVE for 15% off your first order.
- Our Place | Head to https://fromourplace.com/ and use the code DAVE for 10% off your order.
Resources:
- Bryan Johnson’s Blueprint Protocol: https://blueprint.bryanjohnson.com/
- Bryan Johnson’s Don’t Die Movement: https://dontdie.bryanjohnson.com/
- Bryan Johnson’s Kernel: https://www.kernel.com/
- Bryan Johnson’s YouTube Channel: https://www.youtube.com/@bryanjohnson_
- Bryan Johnson’s Instagram: https://www.instagram.com/bryan_johnson_
- Dave Asprey’s Linktree: https://linktr.ee/daveasprey
- Dave Asprey’s Book ‘Smarter Not Harder’ is out now: https://daveasprey.com/books
- Danger Coffee by Dave Asprey: https://www.instagram.com/dangercoffeeofficial/
- Supplements by Dave Asprey: https://shopsuppgradelabs.com
- Join The Human Upgrade Podcast Live – Upgrade Collective: https://www.ourupgradecollective.com
- Own an Upgrade Labs: https://ownanupgradelabs.com
Timestamps and Highlights:
00:00 Introduction and Bold Claims
00:39 Meet Bryan Johnson: The Neuroscience Pioneer
01:23 Kernel: Revolutionizing Brain Measurement
05:51 Biohacking and Longevity
07:30 Facing Criticism and Staying Resilient
16:06 Media Training Insights
19:49 Personal Reflections and Relationships
34:37 Exercise and Longevity
44:46 Optimizing Brain-Body Interface
45:25 Longevity Hacks and Driving Preferences
45:48 Debating Olive Oil and Saturated Fats
46:52 The Blueprint Approach to Health
48:38 Testing and Metrics in Health
52:22 Testosterone and Hormone Protocols
56:27 Exploring Semen Retention
01:00:44 Body Hair and Aesthetics
01:04:26 Psychedelics and Consciousness
01:08:32 Audience Q&A and Final Thoughts
See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.
Get every episode summarized
Each time The Human Upgrade: Biohacking for Longevity & Performance publishes, we email you a written briefing from the transcript — the topics, who appeared, and any specific claims, with the ad reads skipped.
Email me new episodesFree for 3 shows. No card needed.
Hosts & guests
No transcript yet
This episode has not been transcribed. Request it and it moves to the front of the queue.
More episodes
More from The Human Upgrade: Biohacking for Longevity & Performance

If I Had To Lose 50 Pounds FAST, I’d Do THIS : 1532
The Human Upgrade: Biohacking for Longevity & Performance

Raw Garlic, Egg Yolks, Heat Strokes, and Melatonin : 1531
The Human Upgrade: Biohacking for Longevity & Performance

Jenny McCarthy | The 3 Questions You’re NEVER Supposed to Ask : 1530
The Human Upgrade: Biohacking for Longevity & Performance

3 Longevity Drugs I QUIT (And the 4 I Take Instead) : 1529
The Human Upgrade: Biohacking for Longevity & Performance
