TWiV 1124: Clinical update with Dr. Daniel Griffin

In his weekly clinical update, Dr. Griffin reviews the recent statistics on SARS-CoV-2 infection, before discussing methods for sterilizing filtering facepieces, an update to the fall COVID boosters, the emergency use application of a pre-exposure prophylactic and where to find it and drug interaction database, convalescent plasma, the effectiveness of the monoclonal antibody sotrovimab against Omicron variants, what to do when healthcare workers succumb to SARS-CoV-2 infection, the need for better nursing resources, how survivors of COVID-19-associated ARDS exhibited sustained elevation in endothelial dysfunction biomarkers, correlating with the severity of impaired gas exchange, reactivation of latent CMV as a consequence of a SARS-CoV-2 infection, identification of variables that might impact or predict a person's time to recovery from an acute SARS-CoV-2 infection and if COVID-19 patients really have olfactory dysfunction more often than normally smelling individuals.

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Links for this episode

• COVID-19 national trend (CDC)
• COVID-19 deaths (CDC)
• Comparison of methods for sterilizing filtering facepiece respirators (American Journal of Infection Control)
• Booster update already! KP.2 of JN.1-lineage (FDA)
• EUA for pemgarda (FDA)
• Where to get pemgarda (Pemgarda)
• CDC Quarantine guidelines (CDC)
• Early phase of SARs-CoV-2 infection (COVID.gov)
• NIH COVID-19 treatment guidelines (NIH)
• Infectious Disease Society guidelines for treatment and management (ID Society)
• Drug interaction checker (University of Liverpool)
• Molnupiravir safety and efficacy (JMV)
• Convalescent plasma recommendation for immunocompromised (ID Society)
• Revisiting monoclonal antibody therapy, sotrovimab for treatment during Omicron BA.2 and BA.5 (Infection)
• What do when your healthcare provider is infected with SARS-CoV-2 (CDC)
• Managing healthcare staffing shortages (CDC)
• Steroids,dexamethasone at the right time (OFID)
• Anticoagulation guidelines (hematology.org)
• Hospital nurse staffing variation & COVID-19 (International Journal of Nursing Studies)
• Endothelial dysfunction and persistent inflammation severe post-COVID-19 (BMC Medicine)
• Prevalence and risk for CMV reaction due to COVID-19 pneumonia (PLoS One)
• Variables that impact recovery from acute SARS-CoV-2 infetion (JAMA Network Open)
• Reduced olfactory bulb volume with dysfunction after mild SARS-CoV-2 inction (Scientific Reports)
• Contribute to our Floating Doctors fundraiser
• Letters read on TWiV 1124
• Dr. Griffin's COVID treatment summary (pdf)
• Timestamps by Jolene. Thanks!

Intro music is by Ronald Jenkees

Send your questions for Dr. Griffin to [email protected]