Study Deep Dive: Does Aspartame Increase Insulin?

In this episode, Layne Norton, PhD, dissects the landmark 2025 systematic review & meta-analysis in Advances in Nutrition: "The Effects of Aspartame on Glucose, Insulin, and Appetite-Regulating Hormone Responses in Humans". (PMID: 40381807)

This episode is perfect if you've heard claims like "diet soda spikes insulin," "artificial sweeteners cause diabetes," or "aspartame is toxic" — Layne uses this gold-standard review to separate science from fear-mongering.

If you're into evidence-based nutrition, skeptical of viral health scares, or just want to know if your Diet Coke habit is secretly wrecking your metabolism — this episode has the receipts.

Subscribe for more deep-dive breakdowns of the latest research, and drop a comment: Do you use aspartame? Has this changed your view?

SPONSORS

• Outwork Nutrition - Evidence-Based Supplements to Support Your Hard Work: https://outworknutrition.com

• David Protein - Buy 4 cartons, get 1 FREE at: https://davidprotein.com/pages/layne

LAYNE'S COMPANIES

Carbon Diet Coach: https://joincarbon.com/podcast

Outwork Nutrition: https://outworknutrition.com

REPS Research Review: https://biolayne.com/reps

Workout Builder: https://biolayne.com/workout-builder

Team Biolayne: https://biolayne.com/online-coaching

Physique Coaching Academy: https://physiquecoachingacademy.com

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TIMESTAMPS

0:00:00 - Intro

0:02:53 - What is Aspartame

0:05:15 - Health Claims

0:11:26 - How Aspartame is Metabolized

0:14:15 - HRCTs

0:15:56 - Outwork Nutrition

0:18:06 - Study Overview

0:19:25 - Inclusion Criteria

0:31:43 - Results

0:40:38 - David Protein

0:42:13 - Results Cont.

0:49:51 - Discussion

0:58:53 - Conclusion

SHOW NOTES

https://biolayne.com/podcasts/dr-layne-norton-podcast/study-deep-dive-does-aspartame-increase-insulin-episode-20