
technologyFeb 4, 20251:16:30pending
Speculative Decoding and Efficient LLM Inference with Chris Lott - #717
About this episode
Today, we're joined by Chris Lott, senior director of engineering at Qualcomm AI Research to discuss accelerating large language model inference. We explore the challenges presented by the LLM encoding and decoding (aka generation) and how these interact with various hardware constraints such as FLOPS, memory footprint and memory bandwidth to limit key inference metrics such as time-to-first-token, tokens per second, and tokens per joule. We then dig into a variety of techniques that can be used to accelerate inference such as KV compression, quantization, pruning, speculative decoding, and leveraging small language models (SLMs). We also discuss future directions for enabling on-device agentic experiences such as parallel generation and software tools like Qualcomm AI Orchestrator.
The complete show notes for this episode can be found at https://twimlai.com/go/717.
Get every episode summarized
Each time The TWIML AI Podcast (formerly This Week in Machine Learning & Artificial Intelligence) publishes, we email you a written briefing from the transcript — the topics, who appeared, and any specific claims, with the ad reads skipped.
Email me new episodesFree for 3 shows. No card needed.
Hosts & guests
No transcript yet
This episode has not been transcribed. Request it and it moves to the front of the queue.
More episodes
More from The TWIML AI Podcast (formerly This Week in Machine Learning & Artificial Intelligence)

How Capital One Delivers Multi-Agent Systems with Rashmi Shetty - #765
The TWIML AI Podcast (formerly This Week in Machine Learning & Artificial Intelligence)
Apr 16, 202654:18failed

The Race to Production-Grade Diffusion LLMs with Stefano Ermon - #764
The TWIML AI Podcast (formerly This Week in Machine Learning & Artificial Intelligence)
Mar 26, 20261:03:18failed

Agent Swarms and Knowledge Graphs for Autonomous Software Development with Siddh...
The TWIML AI Podcast (formerly This Week in Machine Learning & Artificial Intelligence)
Mar 10, 20261:16:14failed

AI Trends 2026: OpenClaw Agents, Reasoning LLMs, and More with Sebastian Raschka...
The TWIML AI Podcast (formerly This Week in Machine Learning & Artificial Intelligence)
Feb 26, 20261:18:55pending