
scienceMar 1, 202521:55pending
Protein Engineering 101: Designing the Tiny Machines
About this episode
A friendly dive into how scientists reshape proteins—nature’s workhorses—using rational design and directed evolution. We break down structure–function, the tools that reveal 3D shapes (X-ray crystallography, NMR), how diverse protein libraries are built and screened (phage display, selection), and the computational tricks to predict folding (ab initio, homology, fragment-based, threading). Tune in to see how engineered proteins tackle pollution, medicine, sensing, and more.
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