Not All Doses Are Equal: Exploring High vs. Low Dose Ketamine and the Healing Power of Discomfort

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In this episode, Dr. Juan Pablo Galindo breaks down the nuanced differences between psycholytic and psychedelic dosing in Ketamine-Assisted Psychotherapy (KAP)—and why the way we dose matters for therapeutic outcomes.

You’ll learn how lower, talk-friendly doses (psycholytic) support emotional processing in real time, while higher, dissociative doses (psychedelic) offer deeper access to the unconscious. We discuss the therapeutic pros and cons of each approach, and how they can be used intentionally based on clinical goals.

In the second half, we shine a light on a growing concern in ketamine treatment: the overuse of anti-anxiety medications (like benzodiazepines) in IV ketamine clinics when clients feel distressed. Through the lens of Acceptance and Commitment Therapy (ACT), we explore the concept of experiential avoidance—how trying to numb discomfort can actually block healing—and why some of the most difficult moments in therapy are also the most meaningful.

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