March Madness: Duke Leads, Purdue Bettor Wins Big

0:00On March 16th, March madness brackets are out, and the action kicks off with the first four games Tuesday and Wednesday nights at the University of Dayton. This year's number one seeds are Duke, Michigan, Arizona, and Florida, with Duke leading as the overall tournament favorite at Plus 300. Odds, betting lines have Duke ahead of Michigan at Plus 350, Arizona at Plus 400, and Florida at Plus 650. Michigan started as the top pick right after the bracket drop on Sunday, but Duke quickly jumped ahead. Fans are already placing huge wagers, like one better who put down $100,000 on Purdue, the number two seed in the West region, two. Reese the final four at Plus 600 odds. Last year, Florida edge Houston's 65 to 63 for their first title since 2007. Experts are highlighting strong first round picks and pointing out teams like the Penn Quakers as ones to watch against the spread this season. Favorites have crushed underdogs in recent tournaments, but many hope for some Cinderella stories to shake things up early.

1:04With odds now live for every matchup, it's prime time to lock in your bracket picks and bets before the full slate tips off.