INTRO TO LOCAL ANESTHETICS - MECHANISM, STRUCTURE, USES & SIDE EFFECTS │ EP22

In this episode, Professor Rhea Temmermand gives nurse anesthesia residents and aspiring CRNA students a introduction to the pharmacology of LOCAL ANESTHESIA. Discover the fundamental structure, classification, and mechanism of action of these essential drugs, including how they block voltage-gated sodium channels to prevent pain signal transmission. Learn about the critical concept of pKa and its impact on drug effectiveness, explore the pharmacokinetics of esters and amides, and understand key clinical considerations for various administration routes. Professor Temmermand also covers crucial safety aspects, including recognizing and managing local anesthetic systemic toxicity (LAST). Whether you're preparing for boards or enhancing your clinical practice, this episode provides invaluable insights into the pharmacology and practical application of local anesthetics in anesthesiology.

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