Gordan Lauc PhD: Glycans- The Next Biological Longevity Clock?

#011-Glycans are being hailed as possibly the next great biological longevity clock. Today we speak with the leading expert on the subject.  

Gordan Lauc PhD, is Professor of Biochemistry and Molecular biology at the University of Zagreb and Co-Founder and Chief Scientific Officer at GlycanAge. He graduated from the University of Zagreb Faculty of Science in 1992, and obtained PhD in Biochemistry and the University of Zagreb.

Take home points:

Glycans– the third revolution in evolution

Nuclei acids - 4 building blocks [linear]
Proteins -  20 amino acids [linear]
Glycoproteins- 2000+ [nonlinear]

Examples -Blood groups ABO are glycans

Post translational-make protein 

Glycans modifications of proteins lipids and even DNA by sugar

Nonlinear branching oligosaccharide 

    Glucose-monosaccharide-

Post translational modifications-

     Phosphorylation

     Glycosylation

AGE- advanced glycation end products——reaction glucose and proteins- not the same as glycosylation.

Immunoglobulins- older get more pro inflammatory glycans-

Igg glycosylation suppress inflammation

Human glycan project

Health Longevity Secrets show listeners who wish to try The Glyconage longevity clock on themselves can receive a 20% discount enter the code ROBERTLUFKIN at the glycanage.com website.

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