Epigenetics in epilepsy and the Michael Prize: Dr. Katja Kobow

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Katja Kobow is the most recent winner of the Michael Prize, an international award in epilepsy research. Her work focuses on epigenetics and epilepsy, a field that has grown exponentially in only the past 10 to 15 years. Dr. Kobow talked about her research and its potential for epilepsy diagnosis and treatment.

Epigenetics is the bookmarking system or the data management system of our genome. It decides which part of the genome is read, and when to read it. The epigenome is what makes the genome versatile in terms of regulating gene expression.

Epigenetics is crucial for all aspects of brain development and function. It’s also reversible, which has exciting implications for anti-epileptogenic therapies.  

Dr. Kobow is assistant professor at the Institute of Neuropathology at the University Hospital Erlangen, Germany. 

Selected recent publications:
 

DNA methylation-based classification of malformations of cortical development in the human brain (Acta Neuropathologica, 2022)

Molecular diagnostics in drug-resistant focal epilepsy define new disease entities (Brain Pathology, 2021)

Epigenetics explained: a topic “primer” for the epilepsy community by the ILAE Genetics/Epigenetics Task Force (Epileptic Disorders, 2020)

The Michael Prize is awarded in odd-numbered years; entries for the 2023 prize are now open and accepted until December 31, 2022.

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This episode was reported, edited, and produced by Nancy Volkers.

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Sharp Waves content is meant for informational purposes only and not as medical or clinical advice. The International League Against Epilepsy is the world's preeminent association of health professionals and scientists, working toward a world where no person's life is limited by epilepsy. Visit us on Facebook, Twitter, and Instagram.

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The International League Against Epilepsy is the world's preeminent association of health professionals and scientists, working toward a world where no person's life is limited by epilepsy. Visit us on Facebook, Instagram, and LinkedIn.