DESI EM PROJECT - EPISODE 2 - THE ONE WITH "THE KETAMINE"

In this episode, we talk about ketamine and how we have been using it in our department. Our experiences, some anecdotes, some evidence. We are not endorsing that you HAVE to use ketamine, but enlightening you that it can be used and the dogmas regarding it being unsafe are exactly those - DOGMAS. Following are the papers that you may read as references. They will guide you more about ketamine. Hope you enjoy the episode!. Have a Happy New Year! 

Reading material - 

1. Domino EF, Chodoff P, Corssen G. Pharmacologic effects of CI-581, A new dissociative anesthetic, in man. Clin Pharmacol Ther. 1965 May-Jun;6:279-91. doi: 10.1002/cpt196563279. PMID: 14296024.

2. Godwin SA, Burton JH, Gerardo CJ, Hatten BW, Mace SE, Silvers SM, Fesmire FM; American College of Emergency Physicians. Clinical policy: procedural sedation and analgesia in the emergency department. Ann Emerg Med. 2014 Feb;63(2):247-58.e18. doi: 10.1016/j.annemergmed.2013.10.015. Erratum in: Ann Emerg Med. 2017 Nov;70(5):758. PMID: 24438649.

3. Kiureghian E, Kowalski JM. Intravenous ketamine to facilitate noninvasive ventilation in a patient with a severe asthma exacerbation. Am J Emerg Med. 2015 Nov;33(11):1720.e1-2. doi: 10.1016/j.ajem.2015.03.066. Epub 2015 Apr 7. PMID: 25895715.

4. Green SM, Roback MG, Kennedy RM, Krauss B. Clinical practice guideline for emergency department ketamine dissociative sedation: 2011 update. Ann Emerg Med. 2011 May;57(5):449-61. doi: 10.1016/j.annemergmed.2010.11.030. Epub 2011 Jan 21. PMID: 21256625.

5. Godoy DA, Badenes R, Pelosi P, Robba C. Ketamine in acute phase of severe traumatic brain injury "an old drug for new uses?". Crit Care. 2021 Jan 6;25(1):19. doi: 10.1186/s13054-020-03452-x. PMID: 33407737; PMCID: PMC7788834.

6. Cohen L, Athaide V, Wickham ME, Doyle-Waters MM, Rose NG, Hohl CM. The effect of ketamine on intracranial and cerebral perfusion pressure and health outcomes: a systematic review. Ann Emerg Med. 2015 Jan;65(1):43-51.e2. doi: 10.1016/j.annemergmed.2014.06.018. Epub 2014 Jul 23. PMID: 25064742.

7. Verma A, Snehy A, Vishen A, Sheikh WR, Haldar M, Jaiswal S. Ketamine Use allows Noninvasive Ventilation in Distressed Patients with Acute Decompensated Heart Failure. Indian J Crit Care Med. 2019 Apr;23(4):191-192. doi: 10.5005/jp-journals-10071-23153. PMID: 31130793; PMCID: PMC6521817.

8. Shaprio HM, Wyte SR, Harris AB. Ketamine anaesthesia in patients with intracranial pathology. Br J Anaesth. 1972 Nov;44(11):1200-4. doi: 10.1093/bja/44.11.1200. PMID: 4647115.

9. Weingart SD, Trueger NS, Wong N, Scofi J, Singh N, Rudolph SS. Delayed sequence intubation: a prospective observational study. Ann Emerg Med. 2015 Apr;65(4):349-55. doi: 10.1016/j.annemergmed.2014.09.025. Epub 2014 Oct 23. PMID: 25447559.