Cannabis and Tolerance Refresh!

Cannabis and Tolerance Refresh!

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I love this topic, as usual, this is one that’s near-and-dear to me, and is why I like to share with you all. 

Are you feeling sometimes that you’re not getting the same “umph” from your cannabis? Are you getting frustrated? We’ll not for long! 

We’ll provide tips in this episode to assist with that and any of these pesky tolerance issues moving forward!
 

Why is this topic important? 

Developing a tolerance can affect your overall experience with cannabis and potentially lead to increased use and dependence. 

For me, I think it’s the risk of looking elsewhere for your medicine…for something “stronger@ when you don’t need that…especially when you can just take a day or two, reset, and get efficacy from your cannabis again. 

So tune in as we talk about tolerance, what it is, why it happens, and how you can keep your cannabis Always feeling good!

References:

• "Cannabis Tolerance: What It Is and How to Manage It" by Leafly (2019) - https://www.leafly.com/learn/cannabis-tolerance
• "Cannabis Tolerance: Everything You Need to Know" by Verywell Mind (2021) -https://www.leafly.com/learn/cannabis-tolerance
• "Marijuana Tolerance: A Comprehensive Review of the Phenomenon" by Gorelick et al. (2012) - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3570572/

The Science of Tolerance:

• "The Endocannabinoid System and Cannabinoid Receptors in the Brain: Signaling Through CB1 and CB2 Receptors" by Howlett et al. (2010) - https://pubmed.ncbi.nlm.nih.gov/20590555/
• "Toward a Comprehensive Understanding of Cannabinoid Tolerance and Dependence" by Lichtman and Martin (2005) - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2562334/
• "Effect of Oral THC and Smoked Cannabis on Subjective and Physiological Effects" by Hunault et al. (2014) - https://pubmed.ncbi.nlm.nih.gov/24160757/
• "CB1 Cannabinoid Receptor-Mediated Signaling: A Key Target for Interventions in CNS Diseases" by Howlett et al. (2002) - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2366186/
• "Differential Effects of Cannabis Strains and Dabbing on Tolerance and Cannabinoid Receptor Expression in Adolescent Mice" by Renard et al. (2017) - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5379124/
• "Cannabis, Cannabinoids, and Sleep: a Review of the Literature" by Babson et al. (2017) - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5312634
• "Cannabis and Cannabinoids in Pain Management: An Overview" by Whiting et al. (2015) - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5569620/
• "Cannabidiol Attenuates Tolerance to Delta-9-Tetrahydrocannabinol and Reverses Chemically Induced Amygdala Fear Responses" by Pamplona et al. (2018) - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5877694/
• "Cannabidiol Interferes with the Effects of Delta-9-Tetrahydrocannabinol in Human Saliva" by Hartman et al. (2015) - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4714465/
• "Pharmacokinetics of Cannabidiol in Dogs" by Samara et al. (2020) - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7318252/

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