
ANCA Vasculitis and the Complement System, Part 2: On to the Humans
About this episode
The final episode summarizes the human data on complement in ANCA vasculitis, with a quick discussion of the trials of C5a receptor antagonism.
Brought to you by Actemra.
- Intro :10
- Welcome :21
- Recap of previous episodes :22
- In this episode 2:12
- Let's start with neutrophil data 5:24
- Studies in humans 11:54
- A summary of the data so far 21:20
- What does all this amount to? 25:41
- Trials of avacopan 28:25
- Side effect profile 36:25
- Thanks for listening 37:06
Disclosures: Brown reports no relevant financial disclosures.
We'd love to hear from you! Send your comments/questions to Dr. Brown at [email protected]. Follow us on Twitter @HRheuminations @AdamJBrownMD @HealioRheum
References:
Augusto JF, et al. PLoS One. 2016;https://doi.org/10.1371/journal.pone.0158871.
Bekker P, et al. PLoS One. 2016;https://doi.org/10.1371/journal.pone.0164646.
Chen SF, et al. Arthritis Res Ther. 2015;https://doi.org/10.1186/s13075-015-0656-8.
Falk RJ, et al. Proc Natl Acad Sci USA. 1990;87:4115-4119.
Gou SJ, et al. Clin J Am Soc Nephrol. 2013;8:1884-1891.
Gou SJ, et al. Kidney Int. 2013;83:129-137.
Jayne DRW, et al. J Am Soc Nephrol. 2017;28:2756-2767.
Jayne DRW, et al. N Engl J Med. 2021;384:599-609.
Merkel PA, et al. ACR Open Rheumatol. 2020;2:662-671.
Get every episode summarized
Each time Healio Rheuminations publishes, we email you a written briefing from the transcript — the topics, who appeared, and any specific claims, with the ad reads skipped.
Email me new episodesFree for 3 shows. No card needed.
Hosts & guests
No transcript yet
This episode has not been transcribed. Request it and it moves to the front of the queue.
More episodes
More from Healio Rheuminations

Healio Community Book Club: A conversation between Leonard Calabrese, DO and Kev...
Healio Rheuminations

Celebrating 101 episodes of Healio Rheuminations with Dr. Leonard Calabrese
Healio Rheuminations

The history of giant cell arteritis: Infections, injections and the man who coul...
Healio Rheuminations

The Unnecessarily Complex Story of Rheumatoid Factor
Healio Rheuminations