32: The Cutting Edge Science of Age Reversal - Part 1

In this can't-miss episode, Buck engages in a riveting conversation with the Dr. Joel Rothman, the Founding Director at UCSB's Center for Aging and Longevity Studies (CALS). Prepare to be transported into the cutting-edge world of scientific discoveries that are reshaping our understanding of aging, potentially unlocking the secrets to unprecedented human longevity. 

This is only the beginning! Be sure to catch the continuation of this talk in episode 33, where we delve even deeper into the groundbreaking breakthroughs at the frontier of aging research including the research being done at CALS.

• 00:02:24 - The Science of Aging: A Deeper Dive
• 00:04:34 - The Human Lifespan
• 00:07:04 - The Different Lifespans of Organisms
• 00:09:12 - Aubrey de Grey Longevity Escape Velocity
• 00:12:27 - The Brain and Aging
• 00:13:47 - David Sinclair's Book Lifespan
• 00:14:23 - The Role of Epigenome in Aging
• 00:19:10 - Genes and Epigenome
• 00:20:41 - DNA Methylation and Chromosome Structure
• 00:22:02 - Information Theory of Aging
• 00:24:14 - Proteostasis or removal of defective proteins
• 00:26:17 - The Horvath Clock and Biological Clocks
• 00:30:50 - Epigenome Reset
• 00:33:53 - Yamanaka Factors 
• 00:37:00 - Extending Healthspan through Cocktails
• 00:41:44 - Challenges in Drug Development