About this episode
Buck discusses Yamanaka Factors and recent experiments where a team led by David Sinclair was successful in reversing cellular age applying the concepts in an experiment.
- 00:00:02 - Is it possible to stop or even reverse the aging process?
- 00:01:48 - 2012 research by Shinya Yamanaka - Yamanaka Factors
- 00:02:50 - Pluripotent stem cells
- 00:03:08 - Revolutionary discovery for the world of regenerative medicine
- 00:03:28 - Salk Institute study using mice with progeria
- 00:03:55 - Doxycycline and improvements in signs of aging
- 00:04:26 - David Sinclair's research to regenerate optic nerves in mice to restore vision
- 00:04:49 - David Sinclair's book on aging research called Lifespan
- 00:05:20 - Epigenome and the aging process
- 00:06:15 - Horvath lab and using Yamanaka factors to reset epigenetic clocks in rats
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