#140 - Gerald Shulman, M.D., Ph.D.: A masterclass on insulin resistance—molecular mechanisms and clinical implications

We discuss:

• Gerald's background and interest in metabolism and insulin resistance (4:30);
• Insulin resistance as a root cause of chronic disease (8:30);
• How Gerald uses NMR to see inside cells (12:00);
• Defining and diagnosing insulin resistance and type 2 diabetes (19:15);
• The role of lipids in insulin resistance (31:15);
• Confirmation of glucose transport as the root problem in lipid-induced insulin resistance (40:15);
• The role of exercise in protecting against insulin resistance and fatty liver (50:00);
• Insulin resistance in the liver (1:07:00);
• The evolutionary explanation for insulin resistance—an important tool for surviving starvation (1:17:15);
• The critical role of gluconeogenesis, and how it's regulated by insulin (1:22:30);
• Inflammation and body fat as contributing factors to insulin resistance (1:32:15);
• Treatment approaches for fatty liver and insulin resistance, and an exciting new pharmacological approach (1:41:15);
• Metformin's mechanism of action and its suitability as a longevity agent (1:58:15);
• More.

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