The Multi-Omics Series Part 2: MTHFR

A multi-omic assessment combines your genetic blueprint (genomics) with laboratory biomarker information (metabolomics) to provide a deeper understanding of the root cause of disease or disease risk. By starting with a specific enzyme and discussing what it does in the body, we can start to map its systemic effects and gather important data. When there are genetic variants in that enzyme many systems can be affected.

Today’s episode discusses the enzyme 5,10 methylenetetrahydrofolate reductase or “MTHFR”. In functional medicine, MTHFR is a common topic that is often debated and misunderstood. We explain what MTHFR does in the body and why it is important. Genetic variants in this enzyme can predispose a person to many clinical conditions but these are not always expressed. Hear why that is, and what you need to assess to get the full picture.

“Genes do not make your destiny, and SNPs do not always manifest themselves as a biological or functional problem.” – Michael Chapman

Today on The Lab Report Podcast:

• 2:30 What is a multi-omics assessment?
• 4:00 The basics of methylation and why it’s important
• 7:00 What is MTHFR and how does it relate to folate and methylation
• 8:55 Possible effects of genetic single nucleotide polymorphisms (SNPs) related to MTHFR
• 11:30 Which profiles and biomarkers can give multi-omic information about MTHFR SNPs?
• 16:45 How do we support patients with MTHFR SNPs, and should we give methylated vitamins
• 22:05 Question of the day: “How common is it to have an MTHFR SNP?”

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Disclaimer: The content and information shared in The Lab Report is for educational purposes only and should not be taken as medical advice. The views and opinions expressed in The Lab Report represent the opinions of Michael Chapman and Patti Devers and their guests.

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