Is A Psychedelic Trip the Derech HaShem?

Is using psychedelic drugs to get close to Hashem a Mitzvah or Aveira?
What about for therapeutic and recreational purposes?
How do psychedelics affect people and what are the side effects?
Are people in the frum world really using these drugs and, if so, how broadly?
How should we think about Rabbanim who use – and advise others to use – psychedelics?