High-frequency oscillations and epilepsy: Clinical and basic science perspectives

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High-frequency oscillations (80 to 500 Hz) are being studied as biomarkers of epileptogenic areas in the brain, as well as markers to be used in epilepsy surgery. Dr. Cecilie Nome leads a discussion about clinical research on HFOs and areas of uncertainty, as well as the importance of basic research in helping to understand this phenomenon.

Publications mentioned during the episode: 

Roehri Eng N, et al. High-frequency oscillations are not better biomarkers of epileptogenic tissues than spikes. 2017. Annals of Neurology

Jacobs J, et al. Removing high-frequency oscillations: A prospective multicenter study on seizure outcome. 2018. Neurology

Zweiphenning W, et al. Intraoperative electrocorticography using high-frequency oscillations or spikes to tailor epilepsy surgery in the Netherlands (the HFO trial): a randomised, single-blind, adaptive non-inferiority trial. 2022. Lancet Neurology

Lisgaras CP et al. High-frequency oscillations (250–500 Hz) in animal models of Alzheimer's disease and two animal models of epilepsy. 2022. Epilepsia

Sharp Waves episodes are meant for informational purposes only, and not as clinical or medical advice.

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