Guerendo Out, Depth Chart Tightens | NFL News

San Francisco 49ers running back Isaac Guerendo is officially sidelined for the first four games after tearing his pectoral muscle in May, moving to the reserve/physically unable to perform list. Once a fourth-string option behind Christian McCaffrey, Jordan James, and rookie Kaelon Black, Guerendo’s injury now solidifies James and Black as the primary backups. He won’t return until at least Week 5—if healthy and the team chooses to bring him back. This underscores how fast NFL rosters can shift with injuries—and how depth charts can tighten overnight.

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