Exploring Encompass RNA PreE (At-Home) Test

Podcast family, we have to be careful what we ask for… Because we might just get it! We have been asking for new ways to predict preeclampsia for close to two decades. Well now we have new biomarker serum tests that are even offered direct- to-consumer. The problem is, what do we do with a positive test?! In a past episode we covered an FDA cleared serum test by Thermo Fisher for use in patients already diagnosed with preeclampsia. Now there is a new blood test which uses cell free RNA, drawn between 18 and 22 weeks of gestation, which can also predict preterm preeclampsia. Does this work? And what do we do when the result shows “high risk” It's a complicated issue. We have to be careful what we ask for. Listen in for details!

1. https://publications.smfm.org/publications/554-acog-clinical-practice-update-biomarker-prediction-of-preeclampsia/

2. ACOG Clinical Practice Update: Biomarker Prediction of Preeclampsia With Severe Features June 2024

3. https://www.healthywomen.org/tech-talk-hp/tools-to-predict-preeclampsia

4. Elovitz, M.A., Gee, E.P.S., Delaney-Busch, N. et al. Molecular subtyping of hypertensive disorders of pregnancy. Nat Commun 16, 2948 (2025). https://doi.org/10.1038/s41467-025-58157-y

5. https://www.businesswire.com/news/home/20250717476669/en/New-Study-in-JAMA-Network-Open-Shows-Current-Approaches-to-Assessing-Preeclampsia-Risk-Are-Failing-the-Majority-of-Pregnant-Moms