Episode 377: Methylene Blue for Mitochondria & Performance: Benefits, Dosing & Risks with Dr. Scott Sherr

In this episode of the Flex Diet Podcast, I sit down with Dr. Scott Sherr to take a deep dive into methylene blue, mitochondrial function, and where the truth lies between online hype and fear. We talk through how methylene blue acts as a redox cycler in the mitochondria, how dosing differs for mitochondrial support versus antimicrobial use, and why high doses or poorly labeled liquid droppers can cause problems. 

Dr. Sherr also shares how he’s used methylene blue with athletes for recovery and endurance, including timing, half-life, and practical ranges he sees most often. We cover how mitochondrial health connects to energy, mood, focus, stress physiology, and recovery, plus resources from Transcriptions and the Health Optimization Medicine and Practice (HOMe/HOPe) framework.

Sponsors:

• TROScriptions TX: https://troscriptions.com/?rfsn=9054607.066ddde&utm_source=refersion&utm_medium=affiliate&utm_campaign=9054607.066ddde
  • CODE: DRMIKE
• Daily Fitness Insider Newsletter: https://flex-diet.kit.com/bfa1510fa8

Coming up:

• ISSN 2026: https://www.sportsnutritionsociety.org/

Available now:

• Grab a copy of the Triphasic Training II book I co-wrote with Cal Deitz here.

Episode Chapters:

• 03:11 Why Methylene Blue Now
• 04:29 Scott Cher Origin Story
• 05:05 Health Optimization Framework
• 07:08 Transcriptions and Safe Sourcing
• 08:46 Natural vs Synthetic Debate
• 11:49 How Methylene Blue Works
• 17:42 Who Benefits Most
• 22:13 Athletic Performance and Recovery
• 29:41 Dosing Timing and MAOI Effects
• 32:13 Mitochondria and Fertility
• 32:28 Energy Anxiety and Brain Fog
• 33:13 Depression Beyond Serotonin
• 35:30 Stress Pathways and Cell Danger
• 37:00 ADHD or Sympathetic Overdrive
• 38:50 Recovery Metrics and Downregulation
• 42:21 GABA Support and BBB Clues
• 47:50 Building Mitochondrial Capacity First
• 51:35 Methylene Blue Dosing Guide
• 57:54 Where to Learn More
• 01:00:24 Podcast Wrap and Disclaimer 

Flex Diet Podcasts you may enjoy:

• Episode 344: Metabolic Adaptations, Lactate, and Training Smarter with Dr. Phil Batterson
  • YouTube: https://www.youtube.com/watch?v=PPZyO1nxSPA
• Episode 320: Unlocking Mitochondrial Secrets with Dr. Hemal Patel
  • YouTube: https://www.youtube.com/watch?v=lQGXtZjJtQw

Connect with Dr Sherr:

• Instagram: https://www.instagram.com/drscottsherr/
• Website: https://drscottsherr.com/
• YouTube: https://www.youtube.com/@drscottsherr

Get In Touch with Dr Mike:

• Instagram: Drmiketnelson
• YouTube: @flexdietcert
• Email: Miketnelson.com/contact-us

Get the Daily Fitness Insider newsletter (free): https://www.miketnelson.com/newsletter