Dr. Mark Hyman on Function Health & GLP-1 microdosing | E2334

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Today's show:

Your doctor almost certainly isn't testing your insulin. Dr. Mark Hyman sits down with Jason to explain the broken system that Function is fixing, and what 100 million biomarkers say about how sick America actually is.

Learn why insulin beats blood sugar as an early warning for TKTKTK. Why might "normal" lab ranges be unreliable? PLUS, how does an expert like Dr. Hyman feel about GLP-1s and psychedelics?

Guests:

Dr. Mark Hyman on X: https://x.com/drmarkhyman

Function: https://www.functionhealth.com/

Relevant Links:

The Dr. Hyman Show — https://podcasts.apple.com/us/podcast/the-dr-hyman-show/id1382804627
Function pricing — https://www.functionhealth.com/pricing
Ezra — the full-body MRI company Function acquired https://ezra.com/
Galleri (GRAIL) — the multi-cancer early detection blood test — https://www.galleri.com/
Tufts / JACC study — the source of the "93% of Americans have metabolic dysfunction" — https://now.tufts.edu/2022/07/05/only-7-american-adults-have-good-cardiometabolic-health
American College of Cardiology — https://www.acc.org/
Dr. Jorge Plutzky — https://www.health.harvard.edu/authors/jorge-plutzky-md
OpenEvidence — https://www.openevidence.com/
Stanford Metabolic Psychiatry Clinic — https://med.stanford.edu/news/all-news/2022/11/metabolic-psychiatry.html
Stanford Medicine on the ibogaine findings → https://med.stanford.edu/news/all-news/2024/01/ibogaine-ptsd.html
Texas SB 2308 — the $50M state investment in ibogaine trials — https://www.texastribune.org/2026/03/31/texas-ibogaine-research-clinical-trials-psychedelics/

Timestamps:

0:00 What Function actually is

6:43 Healthspan vs. sick care

10:16 Odoo - The all-in-one business platform. Your first app is free! Get started today at https://Odoo.com/twist

11:32 A $300 vitamin D test vs. a $10 one

18:08 Should a 25-year-old get a whole-body MRI?

20:42 Northwest Registered Agent - Got a new business idea? Northwest Registered Agent helps you bring it to life. Get a free domain, email, phone number, and more - with no purchase required! Learn more at https://www.northwestregisteredagent.com/twistdomain

24:23 Why medicine is still running on paper

25:41 The study where the chatbot beat the doctors

27:02 micro1, doctors in the loop, and why AI still needs guardrails

28:50 Wearables, records, and the CD-ROM problem

30:07 Rippling - Thanks to our partners at Rippling! Head to https://Rippling.ai/twist and get the only AI built to give you full visibility across your startup and take complex actions across your entire business.

32:51 The wearable that caught Jason's Covid

34:31 Alcohol, sugar, and why almost nobody tests your insulin

40:00 GLP-1s: Jason's 213-to-168 story

42:22 Microdosing GLP-1s, muscle loss, and "skinny fat"

48:48 Overdiagnosing mental illness: SSRIs, Adderall, and a lost decade

50:17 The biology underneath depression and anxiety

54:32 Psychedelics: ketamine, ibogaine, and the second revolution in psychiatry

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