63. Q&A: HRT, MOTS-c, and Cholesterol

Three questions. Three women in very different places. One on HRT and dealing with acne and hair loss she did not sign up for. One who tried MOTS-c and felt absolutely nothing. One whose LDL went up after starting hormones and whose doctor is already talking about a statin.

Tanya answers all three, and each one points toward something the standard conversation is missing.

On the HRT question, she breaks down why acne and hair loss from testosterone are almost always a DHT conversion issue, how a DUTCH test can show exactly how aggressively a woman is converting, and which natural 5-alpha reductase inhibitors, saw palmetto, pumpkin seed oil, spearmint tea, nettle root, and zinc, can reduce that side effect burden. She also covers why the SRD5A1 genetic variant matters here and why the foundational work before starting any hormone protocol changes everything.

On MOTS-c, she explains what it is actually doing, why some women feel nothing when they try it, and what the research suggests about sequencing SS31 first when mitochondrial damage may be part of the picture.

On the LDL question, she covers why the form and delivery of hormones matters for the lipid picture, how phase two liver detoxification connects to rising LDL on HRT, and what it means when the liver is not equipped to handle everything it is being given.

This is a standalone Q&A episode and the first of the month. The September series on HRT starts next week.

MENTIONED IN THIS EPISODE

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